منابع مشابه
Jekyll-Hyde neurotrophins: the story of proNGF.
Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide is both a preferential high-affinity ligand for p75(NTR) (with minimal affinity for trkA) and a p...
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Without regard to patient selection, other than the eligibility requirements for entry into the studies, worldwide overviews of prospective clinical trials demonstrate that adjuvant tamoxifen reduces the annual odds of death for women with invasive breast cancer by approximately 15% over 10–15 years (1). These data raise the provocative question: Should all patients with invasive breast cancer ...
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In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in response to the activating signals and cytokines e...
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belletristic tradition associated with more conventional critics of the period like George Saintsbury or Edmund Gosse. The rise of "professional man" in turn coincides with the final consolidation of power during the nineteenth century in the hands of a capitalist bourgeoisie. 62 By definition professionals are middle class (and in this period male); their discourses are among the means by whic...
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Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells is essential for control of intracellular pathogens and tumors, yet aberrant production of IFN-γ contributes to autoimmunity and inflammation in certain disease settings. These divergent roles are well illustrated in th...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2009
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2008.12.012